185892

Ethyl chloroformate

97%

• Synonym(s): Chloroformic acid ethyl ester
• Linear Formula: ClCOOC₂H₅
• CAS Number: 541-41-3
• Molecular Weight: 108.52
• Beilstein/REAXYS Number: 385653
• EC Number: 208-778-5
• MDL number: MFCD00000644
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851187
• NACRES: NA.22

Properties

• vapor density: 3.74 (vs air)
• Quality Level: 200
• vapor pressure: 3.42 psi ( 20 °C)
• assay: 97%
• form: liquid
• autoignition temp.: 842 °F
• refractive index: n20/D 1.395 (lit.)
• bp: 93 °C (lit.)
• mp: −81 °C (lit.)
• solubility: alcohol: miscible; benzene: miscible; chloroform: miscible; diethyl ether: miscible; water: insoluble
• density: 1.135 g/mL at 25 °C (lit.)
• functional group: chloro
• SMILES string: CCOC(Cl)=O
• InChI: 1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3
• InChI key: RIFGWPKJUGCATF-UHFFFAOYSA-N

Description

Application

• Ethyl chloroformate was used in the synthesis of nitrile oxides.
• It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction.
• It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography.
• It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.
• It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Packaging

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Safety Information

• pictograms: GHS02,GHS06,GHS05
• signalword: Danger
• hcodes: H225,H290,H302,H314,H330
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 60.8 °F
• flash_point_c: 16 °C
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter