PHL89766

Protocatechuic acid

phyproof^® Reference Substance

• Synonym(s): 3,4-Dihydroxybenzoic acid, Protocatechuic acid
• Linear Formula: (HO)₂C₆H₃CO₂H
• CAS Number: 99-50-3
• Molecular Weight: 154.12
• Beilstein/REAXYS Number: 1448841
• MDL number: MFCD00002509
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• assay: ≥98.0% (HPLC)
• form: solid
• manufacturer/tradename: PhytoLab
• mp: 197-200 °C (dec.) (lit.)
• SMILES string: OC(=O)c1ccc(O)c(O)c1
• InChI: 1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
• InChI key: YQUVCSBJEUQKSH-UHFFFAOYSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Application

• Bronchom assuages airway hyperresponsiveness in house dust mite-induced mouse model of allergic asthma and moderates goblet cell metaplasia, sub-epithelial fibrosis along with changes in Th2 cytokines and chemokines.: This study highlights the anti-inflammatory properties of Protocatechuic acid, demonstrating its potential as a natural phenolic compound in pharmacological studies and its role in modulating immune responses (Balkrishna et al., 2024).


• Exploring the Efficacy of Hydroxybenzoic Acid Derivatives in Mitigating Jellyfish Toxin-Induced Skin Damage: Insights into Protective and Reparative Mechanisms.: This research provides insights into the protective and reparative mechanisms of Protocatechuic acid against toxin-induced skin damage, emphasizing its antioxidant properties and applications in biochemistry and dermatology (Geng et al., 2024).


• Patterns of alteration in boar semen quality from 9 to 37 months old and improvement by protocatechuic acid.: This article investigates the role of Protocatechuic acid in improving semen quality, showcasing its benefits in reproductive biology and potential applications as an antioxidant agent in animal science (Hu et al., 2024).


• Phytochemical Analysis and Antioxidant Effects of Prunella vulgaris in Experimental Acute Inflammation.: The study details the antioxidant effects of Protocatechuic acid in mitigating acute inflammation, underlining its importance in pharmacological studies and biochemical assays for anti-inflammatory research (Mirza et al., 2024).


• Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures.: This research highlights the antioxidant potential and phenolic profiling of Protocatechuic acid, making it a valuable reagent for biochemical assays and studies on natural phenolic compounds (Jafernik et al., 2024).

Biochem/physiol Actions

Chemopreventive in several animal models of carcinogenesis. Blocks cell proliferation in the post-initiation phase.

Other Notes

This compound is commonly found in plants of the genus: allium carum cinnamomum curcuma ginkgo humulus melissa pimpinella thymus

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable