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U6625

Sigma-Aldrich

Uridine 5′-triphosphate trisodium salt hydrate

from yeast, Type III, ≥96%

Synonym(s):

UTP Na3

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About This Item

Empirical Formula (Hill Notation):
C9H12N2Na3O15P3 · xH2O
CAS Number:
19817-92-6
Molecular Weight:
550.09 (anhydrous basis)
Beilstein/REAXYS Number:
3585234
MDL number:
MFCD00044310
UNSPSC Code:
12352200
PubChem Substance ID:
24900436
NACRES:
NA.77

biological source

yeast

type

Type III

assay

≥96%

solubility

H2O: soluble 50 mg/mL, clear to slightly hazy, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

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Application

UTP has been used to study its vasodilatory effects on the skeletal muscle cells of diabetic patients. UTP has also been used as a purinergic agonist to study ion transport functions of P2Y2 receptors on rat basolateral membranes.

Biochem/physiol Actions

P2Y receptor agonist.

Preparation Note

Uridine 5′-triphosphate trisodium salt (UTP Na3) hydrate dissolves in water at 50 mg/ml to yield a clear to slightly hazy, colorless solution.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Satyanarayana R Pondugula et al.
BMC research notes, 3, 100-100 (2010-04-20)
The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracrine and autocrine hormones along with their associated intracellular signal
Xiping Chen et al.
FEBS letters, 595(1), 110-122 (2020-10-25)
O-GlcNAcylation is a post-translational modification catalysed by O-GlcNAc transferase (OGT). Missense mutations in OGT have been associated with developmental disorders, OGT-linked congenital disorder of glycosylation (OGT-CDG), which are characterized by intellectual disability. OGT relies on the hexosamine biosynthetic pathway (HBP)
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Shaojie Ding et al.
Human reproduction (Oxford, England), 35(5), 1130-1144 (2020-04-19)
Does P2X ligand-gated ion channel 3 (P2X3) play a role in endometriosis pain? Upregulation of P2X3 in dorsal root ganglia (DRG) tissues via the activating transcription factor 3 (ATF3)/activator protein (AP)-1 pathway contributed to endometriosis-associated hyperalgesia, which could be attenuated
Lilan You et al.
Cell, 176(1-2), 239-253 (2018-12-07)
Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain
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