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T6443

Sigma-Aldrich

Tyrphostin AG 370

≥98%

Synonym(s):

2-Amino-4-(1H-indo-5′-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7

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About This Item

Empirical Formula (Hill Notation):
C15H9N5
CAS Number:
134036-53-6
Molecular Weight:
259.27
MDL number:
MFCD00236449
UNSPSC Code:
12352200
PubChem Substance ID:
329826844

assay

≥98%

form

solid

mp

289 °C

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

NC(\C(=C/c1ccc2[nH]ccc2c1)C#N)=C(\C#N)C#N

InChI

1S/C15H9N5/c16-7-12(15(19)13(8-17)9-18)6-10-1-2-14-11(5-10)3-4-20-14/h1-6,20H,19H2/b12-6-

InChI key

CMMDWEJTQUTCKG-SDQBBNPISA-N

Application

Tyrphostin AG 370 has been used for inhibiting platelet-derived growth factor (PDGF) signaling in human mesenchymal stem cells1,2.

Biochem/physiol Actions

Inhibitor of PDGF-induced cell proliferation.

Caution

Photosensitive

Preparation Note

Tyrphostin AG 370 is soluble in DMSO.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felicia Ng et al.
Blood, 112(2), 295-307 (2008-03-12)
We compared the transcriptomes of marrow-derived mesenchymal stem cells (MSCs) with differentiated adipocytes, osteocytes, and chondrocytes derived from these MSCs. Using global gene-expression profiling arrays to detect RNA transcripts, we have identified markers that are specific for MSCs and their
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose

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