Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML3024

Sigma-Aldrich

Isoliensinine

≥98% (HPLC)

Synonym(s):

(+)-Isoliensinine, (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$86.92
25 MG
$295.00

$86.92

List Price$91.50Save 5%
Web-Only Promotion

Available to ship onApril 15, 2025Details


Request a Bulk Order

Select a Size

Change View
5 MG
$86.92
25 MG
$295.00

About This Item

Empirical Formula (Hill Notation):
C37H42N2O6
CAS Number:
Molecular Weight:
610.74
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

$86.92

List Price$91.50Save 5%
Web-Only Promotion

Available to ship onApril 15, 2025Details


Request a Bulk Order

Quality Level

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 45.0 to 55.0°, c = 0.5 in acetone

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CN1[C@H](CC(C=C2)=CC=C2OC)C3=C(C=C(C(OC4=C(O)C=CC(C[C@@H]5C(C=C(O)C(OC)=C6)=C6CCN5C)=C4)=C3)OC)CC1

InChI

1S/C37H42N2O6/c1-38-15-13-26-20-36(44-5)37(22-29(26)30(38)16-23-6-9-27(42-3)10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(43-4)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1

InChI key

AJPXZTKPPINUKN-FIRIVFDPSA-N

Biochem/physiol Actions

Isoliensinine is a major bisbenzylisoquinoline alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects. It induces apoptosis in triple negative breast cancer cells through induction of ROS and p38 MAPK/JNK activation, while showing only mild effects on normal MCF-10A cells. Isoliensinine shows chemosensitizing properties in several cancer cells. It appears that if augments cisplatin uptake int cancer cells.
alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service