Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML1224

Sigma-Aldrich

Torin2

≥98% (HPLC)

Synonym(s):

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$150.00
25 MG
$594.00

$150.00

In StockDetails

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$150.00
25 MG
$594.00

About This Item

Empirical Formula (Hill Notation):
C24H15F3N4O
CAS Number:
1223001-51-1
Molecular Weight:
432.40
UNSPSC Code:
12352200
NACRES:
NA.77

$150.00

In StockDetails

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

Storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

Inchi Key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

Application

Torin2 has been used:
  • to examine its effect on LC3B-II levels in BORCS5- KO cells[1]
  • to determine its potent activity (IC50 less than 1 μM) against A2780-cis ovarian cancer cells[2]
  • in western blot analysis[3]

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000053041
0000053041
0000202689
0000200976
0000200976

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 4

1 of 4

Resveratrol ≥99% (HPLC)

Sigma-Aldrich

R5010

Resveratrol

Rapamycin VETRANAL®, analytical standard

Supelco

37094

Rapamycin

Dorsomorphin ≥98% (HPLC)

Sigma-Aldrich

P5499

Dorsomorphin

Rapamycin ≥95% (HPLC), powder

Sigma-Aldrich

553210

Rapamycin

Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
Sima N, et al.
Translational Oncology, 11(4), 1053-1064 (2018)
BORC coordinates encounter and fusion of lysosomes with autophagosomes
Jia R, et al.
Autophagy, 13(10), 1648-1663 (2017)
AMPK promotes induction of a tumor suppressor FLCN through activation of TFEB independently of mTOR
Collodet C, et al.
bioRxiv, 499921-499921 (2018)
Dan Song et al.
Environmental toxicology, 37(7), 1551-1562 (2022-03-04)
The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)-induced apoptosis and oxidative damage in FLK-BLV cells. The results showed that BPA reduced cell viability in a dose- and time-dependent
Peter J Mullen et al.
Nature communications, 12(1), 1876-1876 (2021-03-27)
Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. Here we profile metabolic changes conferred by SARS-CoV-2 infection in kidney epithelial cells
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service