Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML1173

Sigma-Aldrich

Lubiprostone

≥98% (HPLC)

Synonym(s):

(11a,15R)-11,15-Epoxy-16,16-difluoro-15-hydroxy-9-oxo-prostan-1-oic acid, Ru 0211, Spi 0211

Sign Into View Organizational & Contract Pricing

Select a Size

10 MG
$108.90
50 MG
$342.30

$108.90

List Price$121.00Save 10%
Web-Only Promotion

Available to ship onApril 15, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
10 MG
$108.90
50 MG
$342.30

About This Item

Empirical Formula (Hill Notation):
C20H32F2O5
CAS Number:
136790-76-6
Molecular Weight:
390.46
UNSPSC Code:
12352200
NACRES:
NA.77

$108.90

List Price$121.00Save 10%
Web-Only Promotion

Available to ship onApril 15, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

FC(F)([C@@]1(O[C@H]2[C@@H]([C@@H](C(=O)C2)CCCCCCC(=O)O)CC1)O)CCCC

InChI

1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15+,17+,20+/m0/s1

InChI key

WGFOBBZOWHGYQH-DKYLXPRQSA-N

Biochem/physiol Actions

Lubiprostone helps to enhance intestinal permeability in humans. Hence it may inhibit leaky gut syndrome.[1]
Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels.
Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels. Some reports suggest that lubiprostone opens CFTR or both CFTR and ClC-2 through interactions with the prostaglandin receptor EP4. Lubiprostone is used clinically to treat idiopathic chronic constipation and irritible bowel syndrome.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000144644
0000120361
0000120360
0000118631

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers
Kato T, et al.
Testing, 12(4), e0175626-e0175626 (2017)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service