Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML1087

Sigma-Aldrich

Sumanirole maleate

≥98% (HPLC)

Synonym(s):

(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate, (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate, CID 9818479 maleate, PNU-95,666 maleate

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$106.20
25 MG
$427.50

$106.20

List Price$118.00Save 10%

In StockDetails

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$106.20
25 MG
$427.50

About This Item

Empirical Formula (Hill Notation):
C11H13N3O · C4H4O4
CAS Number:
179386-44-8
Molecular Weight:
319.31
MDL number:
MFCD09832637
UNSPSC Code:
12352200
PubChem Substance ID:
329825464
NACRES:
NA.77

$106.20

List Price$118.00Save 10%

In StockDetails

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -22 to -32°, c = 1 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O

InChI

1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1

InChI key

VOJRMYBBPKNLLI-ORHWHDKWSA-N

application

Sumanirole maleate has been used as a dopamine type 2 receptor (D2R) agonist to study its effects on spatial learning and memory in rats.[1][2]

Biochem/physiol Actions

Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.
Sumanirole is a highly selective and potent dopamine D2 receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000371933
0000371935
0000368403
0000368403
0000371935

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Dopamine hydrochloride

Sigma-Aldrich

H8502

Dopamine hydrochloride

Spatial working memory in male rats: pre-experience and task dependent roles of dopamine D1-and D2-like receptors
Bezu M, et al.
Frontiers in Behavioral Neuroscience, 11, 196-196 (2017)
Matthew F Lazenka et al.
The Journal of pharmacology and experimental therapeutics, 362(1), 14-23 (2017-04-16)
Clinically significant pain often includes a decrease in both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists
Dopamine type 1-and 2-like signaling in the modulation of spatial reference learning and memory
Feyissa D D, et al.
Behavioural Brain Research, 362, 173-180 (2019)
Anna Niewiarowska-Sendo et al.
Biochimica et biophysica acta, 1864(10), 1855-1866 (2017-08-02)
In recent years a wide range of studies have shown that G protein-coupled receptors modulate a variety of cell functions through the formation of dimers. For instance, there is growing evidence for the dimerization of bradykinin or dopamine receptors, both
Yasunori Haranishi et al.
Pharmacology, biochemistry, and behavior, 195, 172964-172964 (2020-06-07)
The descending serotonergic pathway, from the brainstem to spinal cord, modulates various aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT)1A and 5-HT2A receptors play pivotal roles in pain modulation. Perospirone is a novel atypical antipsychotic that serves as a 5-hydroxytryptamine
View All Related Papers

Articles

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service