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SML0247

Sigma-Aldrich

Rizatriptan benzoate salt

≥98% (HPLC)

Synonym(s):

MK-462, N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt

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About This Item

Empirical Formula (Hill Notation):
C15H19N5 · C7H6O2
CAS Number:
145202-66-0
Molecular Weight:
391.47
MDL number:
MFCD00866224
UNSPSC Code:
12352200
PubChem Substance ID:
329825257
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥5 mg/mL

storage temp.

room temp

SMILES string

OC(=O)c1ccccc1.CN(C)CCc2c[nH]c3ccc(Cn4cncn4)cc23

InChI

1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)

InChI key

JPRXYLQNJJVCMZ-UHFFFAOYSA-N

Gene Information

human ... HTR1B(3351) , HTR1D(3352)

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Biochem/physiol Actions

Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Piero Barbanti et al.
The journal of headache and pain, 13(5), 407-414 (2012-03-31)
The objective and background is to confirm in a double-blind, placebo-controlled study the high triptan response rates we had previously reported in an open study in migraine patients with unilateral cranial autonomic symptoms. In this randomized, double-blind, placebo-controlled study 80
Amelia M Avachat et al.
Carbohydrate polymers, 91(2), 537-542 (2012-11-06)
Mucoadhesive buccal films were developed using tamarind seed xyloglucan (TSX) as novel mucoadhesive polysaccharide polymer for systemic delivery of rizatriptan benzoate through buccal route. Formulations were prepared based on 3(2) factorial design with concentrations of TSX and carbopol 934P (CP)
Thomas Müller et al.
Clinical neuropharmacology, 34(6), 206-209 (2011-10-15)
Triptans and analgetic nonsteroidal inflammatory drugs reduce acute pain syndromes in migraine. A further treatment option for an acute headache attack in patients with migraine may be the application of cyclooxygenase-2-specific inhibitors, as they have anti-inflammatory and analgesic properties. The
Types of colitis based on histology.
Muhammed Sherid et al.
Disease-a-month : DM, 57(9), 457-489 (2011-09-29)
Robert MacNeill et al.
Bioanalysis, 4(10), 1163-1173 (2012-06-02)
In the context of matrix effects in bioanalytical LC-MS/MS, a speculative link between free cholesterol, the recoveries of the compound from three common extraction procedures, and response enhancement was qualitatively investigated. Injections on-column of cholesterol both in solution and extracts
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