Unfortunately, this product is not tested to determine the molecular weight and information is limited. The length of poly(g) chains is not determined. Polyguanylic acid is a mixture of different and wide ranging molecules, therefore the number of bases is not determined. There is no size limiting or selecting step during the production process. Historical information is available on past lots, which were assayed by both LALLS assay and a formaldehyde denaturing system. Analysis using the denaturing system indicates a wide range of <80,000 to 500,000 with the greatest density at <80,000 to 210,000 . Two past lots have been analyzed by LALLS resulting in estimated molecular weights of 385,000 and 482,000 daltons.
P4404
Polyguanylic acid potassium salt
lyophilized powder
Synonym(s):
Poly(G) potassium salt
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5 MG
$163.00
25 MG
$576.00
About This Item
$163.00
Check Cart for Availability
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biological source
enzyme from (synthesis)
Quality Level
assay
≥95% (TLC)
form
lyophilized powder
quality
≤5% free nucleotides
solubility
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow
Storage temp.
−20°C
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General description
Application
Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine.
Polyguanylic acid potassium salt has been used:
- as a ligand for surface neuropilin-1 (NRP1) for internalization studies[3]
- for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method[4]
- as a synthetic polynucleotide for agarose gel electrophoresis analysis[5]
Biochem/physiol Actions
Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.[3]
Preparation Note
Prepared from GDP using polynucleotide phosphorylase
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ligand interaction with cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonged or excessive signaling from extracellular ligands. Compounds that induce internalization of surface receptors prevent ligand binding to cognate cell-surface receptors serving as inhibitors. Here, we show
Y Kikuchi et al.
Biochimica et biophysica acta, 476(4), 287-294 (1977-06-17)
Polyguanylic acid (poly(G)) was synthesized from GDP in a yield of 60-75% by Thermus thermophilus polynucleotide phosphorylase (polyribonucleotide: orthophosphate nucleotidyltransferase, EC 2.7.7.8) at 70 degrees C, pH 8.5 in the presence of Mg2+. The yield was dependent on the ratio
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Chromosomes in vertebrates are protected at both ends by telomere DNA composed of tandem (TTAGGG)n repeats. DNA replication produces a blunt-ended leading strand telomere and a lagging strand telomere carrying a single-stranded G-rich overhang at its end. The G-rich strand
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Guanosine monophosphate (GMP) in aqueous solutions has been studied with femtosecond broad-band transient absorption spectroscopy and by quantum-mechanical calculations. The sample was excited at 267 or 287 nm and probed between 270 and 1000 nm with 100 fs resolution, for
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What is the average length of the poly(g) chains?
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