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N2287

Sigma-Aldrich

N744 tosylate

≥90% (HPLC), solid

Synonym(s):

3-(2-Hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5-methoxy-2-benzothiazolylidene]methyl]-1-butenyl]-5-methoxybenzothiazolium tosylate

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About This Item

Empirical Formula (Hill Notation):
C25H29N2O4S2 · C7H7O3S
CAS Number:
72616-22-9
Molecular Weight:
656.83
MDL number:
MFCD00143018
UNSPSC Code:
12352200
PubChem Substance ID:
24724546

assay

≥90% (HPLC)

form

solid

storage condition

protect from light

color

purple/blue

solubility

DMSO: ~10 mg/mL

storage temp.

−20°C

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CCC(\C=C2/Sc3ccc(OC)cc3N2CCO)=C/c4sc5ccc(OC)cc5[n+]4CCO

Biochem/physiol Actions

Inhibitor of tau aggregation.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
065K4605

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Carmen Chirita et al.
Biochemistry, 43(10), 2879-2887 (2004-03-10)
Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments comprised of the microtubule associated protein tau. Because animal model studies suggest that a toxic gain of function accompanies tau aggregation in neurons, selective pharmacological inhibitors of the

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