M2727

Mexiletine hydrochloride

≥98% (GC), powder, sodium channel blocker

• Synonym(s): 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride, 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₇NO · HCl
• CAS Number: 5370-01-4
• Molecular Weight: 215.72
• EC Number: 250-825-7
• MDL number: MFCD00216024
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278542
• NACRES: NA.77

Properties

• Product Name: Mexiletine hydrochloride, powder
• assay: ≥98% (GC)
• Quality Level: 200
• form: powder
• color: white to off-white
• solubility: methanol: 50 mg/mL
• originator: Boehringer Ingelheim
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(N)COc1c(C)cccc1C
• InChI: 1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChI key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Description

General description

Mexiletine is a class I B antiarrhythmic[1] and an analog of lidocaine.[2] It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation.[3]

Application

Mexiletine hydrochloride has been used as a sodium channel blocker:

• expressed in chinese hamster ovary cells[4]
• in human embryonic kidney (HEK) cells for whole cell patch-clamp studies[5]
• electrophysiology studies in HEK cells expressing Nav1.7 protein[6]

Biochem/physiol Actions

Mexiletine is a potent sodium channel blocker.[1] It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain[2] Mexiletine is used for treating myotonia in sodium channelopathies[7] and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness.[1] Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia.[7]

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable