M204
p-MPPI monohydrochloride
solid, ≥98% (HPLC)
Synonym(s):
4-Iodo-N-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)benzamide monohydrochloride
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About This Item
Empirical Formula (Hill Notation):
C25H27IN4O2 · HCl
CAS Number:
Molecular Weight:
578.87
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: 2.4 mg/mL
SMILES string
Cl.COc1ccccc1N2CCN(CC2)CCN(C(=O)c3ccc(I)cc3)c4ccccn4
Gene Information
human ... HTR1A(3350)
Biochem/physiol Actions
Selective 5-HT1A serotonin receptor antagonist that crosses the blood-brain barrier.
Caution
Solutions are heat sensitive.
Legal Information
Manufactured and sold under license from University of Pennsylvania, U.S. Patent 5,744,121.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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H F Kung et al.
Life sciences, 55(19), 1459-1462 (1994-01-01)
A potential 5-HT1A receptor antagonist, p-MPPI, 4-(2'-methoxy-)phenyl-1-[2'-(n-2"-pyridinyl)-p-iodobenzamido-]ethy l- piperazine, was developed. The [125I]p-MPPI demonstrated high affinity and selectivity toward 5-HT1A receptors; Kd = 0.36 nM and Bmax = 264 fmol/mg of protein in rat hippocampal membrane homogenates. The binding is
M P Kung et al.
The Journal of pharmacology and experimental therapeutics, 272(1), 429-437 (1995-01-01)
Binding characteristics of a radioiodinated serotonin-1A (5-HT1A) receptor antagonist, 4-(2'-methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p- iodobenzamido]-ethyl-piperazine ([125I]p-MPPI) were evaluated using in vitro homogenate binding and autoradiographic techniques in rat brains. [125I]p-MPPI displayed a Kd value of 0.32 +/- 0.04 nM (in the presence of MgCl2)
In vivo binding of [125I]4-(methoxyphenyl)-1-[2'-(N-2″-pyridinyl)-p-iodo-benzamido]-ethylpiperazine, p-MPPI, to 5HT1A receptors in rat brain.
Kung, et al.
Synapse, 18, 459-459 (1994)
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