M0757

Isopropyl myristate

≥90% (GC)

• Synonym(s): Isopropyl tetradecanoate, Myristic acid isopropyl ester
• Linear Formula: CH₃(CH₂)₁₂COOCH(CH₃)₂
• CAS Number: 110-27-0
• Molecular Weight: 270.45
• Beilstein/REAXYS Number: 1781127
• EC Number: 203-751-4
• MDL number: MFCD00008982
• UNSPSC Code: 12352211
• PubChem Substance ID: 57654344
• NACRES: NA.25

Properties

• biological source: synthetic (organic)
• assay: ≥90% (GC)
• form: liquid
• refractive index: n20/D 1.434 (lit.)
• bp: 193 °C/20 mmHg (lit.)
• mp: ~3 °C (lit.)
• density: 0.85 g/mL at 25 °C (lit.)
• functional group: ester
• lipid type: saturated FAs
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCCCCCC(=O)OC(C)C
• InChI: 1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
• InChI key: AXISYYRBXTVTFY-UHFFFAOYSA-N

Description

Application

• Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride.: This study discusses the design of a transdermal drug delivery system for glimepiride, utilizing matrix diffusion mechanisms potentially incorporating Isopropyl Myristate to enhance permeation (Akram et al., 2018).


• Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole.: This article evaluates formulations incorporating Isopropyl Myristate for enhanced dermal delivery of clotrimazole, highlighting its role in improving drug solubility and skin absorption rates (Zhang and Michniak-Kohn, 2018).

Biochem/physiol Actions

Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres. Isopropyl myristate is used as a oil phase component in the formulation of microemulsion systems.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: awg
• flash_point_f: >302.0 °F
• flash_point_c: > 150 °C
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)