The product should be stored at room temperature upon receipt. It is soluble in water at a concentration greater than 10 mg/ml. However, stock solutions should be stored at -20°C.
C5976
CL 316,243 hydrate
≥98% (HPLC), powder, β3 adrenoceptor agonist
Synonym(s):
Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate
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5 MG
$261.25
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$965.70
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5 MG
$261.25
25 MG
$965.70
About This Item
Empirical Formula (Hill Notation):
C20H18ClNNa2O7 · xH2O
CAS Number:
Molecular Weight:
465.79 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
CL 316,243 hydrate, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 10 mg/mL, clear
originator
Wyeth
storage temp.
room temp
SMILES string
O.[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c3cccc(Cl)c3
InChI
1S/C20H20ClNO7.2Na.H2O/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;;1H2/q;2*+1;/p-2/t11-,15+;;;/m1.../s1
InChI key
BFEWLXURNRQQLY-BELDDISZSA-L
Gene Information
human ... ADRB3(155)
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Application
CL 316,243 hydrate has been used:
- as a β-agonists to inject mice and study its effect on the expression of mammalian major facilitator superfamily domain-containing protein (Mfsd2a)[1]
- as an adrenergic agonist to stimulate adrenergic response in order to study the metabolic activity of brown, beige and white adipose tissues in mice[2]
- as a β3-adrenergic agonist to inject mice for in vivo lipolytic challenge[3]
Biochem/physiol Actions
β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor.[4] It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite.[5]
CL 316,243 is a β3 adrenoceptor agonist; anti-obesity agent.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Customers Also Viewed
Metabolic activity of brown,?beige,? and white adipose tissues in response to chronic adrenergic stimulation in male mice
Labbe SM, et al.
American Journal of Physiology. Endocrinology and Metabolism, 311(1), E260-E268 (2016)
Y Igawa et al.
British journal of pharmacology, 126(3), 819-825 (1999-04-03)
The possible existence of a beta3-adrenergic receptor (beta3-AR) in the human detrusor muscle was investigated by in vitro functional studies and analysis of mRNA expression. Isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the human detrusor. The rank
Evgeny Kanshin et al.
Proteomics, 9(22), 5067-5077 (2009-11-19)
Most phosphoproteomic studies to date have been limited to the identification of phosphoproteins and their phosphorylation sites, and have not assessed the stoichiometry of protein phosphorylation, a critical parameter reflecting the dynamic equilibrium between phosphorylated and non-phosphorylated pools of proteins.
Naoki Aizawa et al.
Neurourology and urodynamics, 29(5), 771-776 (2009-10-10)
It has been suggested that beta(3)-adrenoceptor (beta(3)-AR) agonists affect not only the efferent but also the afferent pathways innervating the bladder. In addition, prostaglandin E(2) (PGE(2)) causes bladder hyperactivity in conscious rats. We investigated the direct effects of a beta(3)-AR
Intracerebroventricular administration of the beta3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus
Castillo-Melendez M, et al.
Neuroscience Letters, 290(3), 161-164 (2000)
Articles
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What are the best storage conditions for item C5976 upon receipt? Also, what solvent is ideal for preparing stock solutions, and how should stock solutions be stored?
1 answer-
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What temperature to store once mixed with H2O?
1 answer-
Solutions should be prepared fresh and used the same day. Other sources suggest the solution may be stable when stored in tightly sealed aliquots at -20°C for up to 1 month. This information has not been validated.
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