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A4330

Sigma-Aldrich

4′-Aminomethyltrioxsalen hydrochloride

Synonym(s):

4′-Aminomethyl-4,5′,8-trimethylpsoralen hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H15NO3 · HCl
CAS Number:
62442-61-9
Molecular Weight:
293.75
MDL number:
MFCD00134837
UNSPSC Code:
12352200
PubChem Substance ID:
24890846
NACRES:
NA.77

form

powder

Quality Level

200

solubility

H2O: 1 mg/mL
DMSO: 2 mg/mL

storage temp.

2-8°C

SMILES string

CC1=CC(=O)Oc2c(C)c3oc(C)c(CN)c3cc12

InChI

1S/C15H15NO3/c1-7-4-13(17)19-14-8(2)15-11(5-10(7)14)12(6-16)9(3)18-15/h4-5H,6,16H2,1-3H3

InChI key

WBIICVGYYRRURR-UHFFFAOYSA-N

Application

4′-Aminomethyltrioxsalen hydrochloride inactivates DNA and RNA viruses, including HIV-1. 4′-Aminomethyltrioxsalen hydrochloride can covalently bind to nucleic acids when irradiated with UV light.

Biochem/physiol Actions

4′-Aminomethyltrioxsalen hydrochloride is used to inactivate DNA and RNA viruses, including HIV-1, by nucleic acid cross-linking followed by UV irradiation.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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M Beltrame et al.
The EMBO journal, 11(4), 1531-1542 (1992-04-01)
It has long been known that U3 can be isolated hydrogen bonded to pre-ribosomal RNAs, but the sites of interaction are poorly characterized. Here we show that yeast U3 can be cross-linked to 35S pre-rRNA both in deproteinized extracts and
H Du et al.
RNA (New York, N.Y.), 7(1), 133-142 (2001-02-24)
Base pairing between the 5' end of U1 snRNA and the conserved 5' splice site of pre-mRNA is important for commitment complex formation in vitro. However, the biochemical mechanisms by which pre-mRNA is initially recognized by the splicing machinery is
J A Grass et al.
Blood, 91(6), 2180-2188 (1998-04-16)
A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that
W S Groene et al.
Journal of virological methods, 38(1), 93-102 (1992-07-01)
The use of the synthetic psoralen 4'-aminomethyl-4,5',8-trimethylpsoralen hydrochloride (AMT) is described for the inactivation of infectious rotavirus, a member of the viral family Reoviradae with a double-stranded RNA genome. This method not only provides complete inactivation of the virus but
M A Reynolds et al.
Bioconjugate chemistry, 3(5), 366-374 (1992-09-11)
A method is reported for conjugating an analog of 4'-(aminomethyl)-4,5',8- trimethylpsoralen to methylphophonate oligonucleotides. This method enables the psoralen moiety to be coupled to the phosphonate backbone between any two desired bases in a sequence. When hybridized to a target
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