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A0835

Sigma-Aldrich

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

Synonym(s):

Ac-DEVD-CHO

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1 MG
$166.00
5 MG
$572.00

About This Item

Empirical Formula (Hill Notation):
C20H30N4O11
CAS Number:
169332-60-9
Molecular Weight:
502.47
MDL number:
MFCD00671412
UNSPSC Code:
12352209
PubChem Substance ID:
24890193
NACRES:
NA.32

$166.00

In StockDetails

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biological source

synthetic

Quality Level

100

assay

≥95%

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834) , CASP3(836) , CASP7(840) , CASP8(841)

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.[1]

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples,[2] smooth muscle cells[3] and Jurkat T-cells.[4]

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.[1]
Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ4792
BCCC7362
BCCB3851
BCBV6599
BCBR4557V

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Carles Solà-Riera et al.
Scientific reports, 9(1), 834-834 (2019-01-31)
Orthohantaviruses, previously known as hantaviruses, are zoonotic viruses that can cause hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) in humans. The HPS-causing Andes virus (ANDV) and the HFRS-causing Hantaan virus (HTNV) have anti-apoptotic effects. To investigate
Yong-Bo Li et al.
Insect biochemistry and molecular biology, 79, 73-86 (2016-10-26)
Autophagy regulates cell survival (or cell death in several cases), whereas apoptosis regulates cell death. However, the relationship between autophagy and apoptosis and the regulative mechanism is unclear. We report that steroid hormone 20-hydroxyecdysone (20E) promotes switching from autophagy to
Florian Guisier et al.
PloS one, 12(7), e0180576-e0180576 (2017-07-04)
Prediction of treatment outcome of non-small cell lung cancer (NSCLC) with EGFR inhibitors on the basis of the genetic analysis of the tumor can be incorrect in case of rare or complex mutations, bypass molecular activation pathways, or pharmacodynamic variations.
An-Cheng Huang et al.
Journal of ethnopharmacology, 194, 1043-1050 (2016-11-12)
Bufalin, a component of Chan Su (frog), has been shown to have biological activities including anti-tumor effects. Gefitinib has been used as an anti-cancer drug in lung cancer patients; however, some patients eventually become gefitinib resistant. In this study, we
H Ruetten et al.
Journal of the American College of Cardiology, 38(7), 2063-2070 (2001-12-12)
The aim of this study was to investigate whether the caspase-3 inhibitor Ac-DEVD-CHO functionally improves stunned myocardium. Degradation of troponin I contributes to the pathogenesis of myocardial stunning, whereas the role of apoptosis is unknown. Caspase-3 is an essential apoptotic
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