86614

Tetraethylammonium chloride

BioUltra, for molecular biology, ≥99.0% (AT)

• Synonym(s): Etamon chloride, TEAC, TEA chloride
• Linear Formula: (C₂H₅)₄N(Cl)
• CAS Number: 56-34-8
• Molecular Weight: 165.70
• Beilstein/REAXYS Number: 3563247
• EC Number: 200-267-5
• MDL number: MFCD00011828
• UNSPSC Code: 12352107
• PubChem Substance ID: 57653171
• NACRES: NA.26

Properties

• grade: for molecular biology
• Quality Level: 100
• product line: BioUltra
• assay: ≥99.0% (AT)
• form: powder
• mol wt: 165.70 g/mol
• technique(s): gas chromatography (GC): suitable
• impurities: DNases, none detected; RNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected
• solubility: H₂O: 1 M at 20 °C, clear, colorless
• anion traces: bromide (Br^-): ≤500 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.03; λ: 280 nm A_max: 0.03
• SMILES string: [Cl-].CC[N+](CC)(CC)CC
• InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
• InChI key: YMBCJWGVCUEGHA-UHFFFAOYSA-M

Description

General description

Tetraethylammonium (TEA), a simple quaternary ammonium compound, is commonly used to block potassium channels. It can physically enter the pore and block the channel. Additionally, TEA either imitates or antagonizes the actions of choline and acetylcholine, two other quaternary ammonium ions.[1]

Application

Tetraethylammonium chloride has been used:

• as a pharmacological agent in electrophysiology to study its pharmacological effects on Cnidarians[2]
• as a component in refolding buffer for protein refolding[3]
• to puff onto isolated patches to block voltage-gated K⁺ (Kv3) channels and post-hoc evaluation[4]

Features and Benefits

• Assay: ≥99.0% (AT), BioUltra, for molecular biology
• Suitable for gas chromatography (GC)

Other Notes

TEACl method of DNA-DNA hybridization[5]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 201.2 °F - closed cup
• flash_point_c: 94 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves