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83875

Sigma-Aldrich

D-Ribose 5-phosphate disodium salt dihydrate

≥99% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C5H9Na2O8P · 2H2O
CAS Number:
207671-46-3
Molecular Weight:
310.10
MDL number:
MFCD00149349
UNSPSC Code:
12352201
PubChem Substance ID:
57652973
NACRES:
NA.25

assay

≥99% (TLC)

form

powder

impurities

≤5% solvent (ethanol, methanol)
6-15% water

color

light yellow

solubility

H2O: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

O.O.[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)C=O

InChI

1S/C5H11O8P.2Na.2H2O/c6-1-3(7)5(9)4(8)2-13-14(10,11)12;;;;/h1,3-5,7-9H,2H2,(H2,10,11,12);;;2*1H2/q;2*+1;;/p-2/t3-,4+,5-;;;;/m0..../s1

InChI key

ROFJYRUKQPRHKK-WFAHMUOKSA-L

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Application

D-Ribose 5-phosphate is used as a substrate to identify, differentiate and characterize ribose-5-phosphate isomerase(s) and phosphopentomutase(s). Ribose 5-phosphate is used to study the processes and effects of glycation in vivo and in vitro.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
For the synthesis of 5-phospho-D-ribosyl α-1-pyrophosphate; Isolation of transketolase

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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A Mocali et al.
European journal of biochemistry, 180(1), 213-219 (1989-03-01)
Transketolase has been purified for the first time from human leukocytes, according to a new procedure which consists of three conventional steps. The enzyme was finally detached from CM-cellulose by specific elution with a D-xylulose-5-phosphate/D-ribose-5-phosphate mixture and the isolated product
A. Gross et al.
Journal of the American Chemical Society, 105, 7428-7428 (1983)
Nisreen Wahwah et al.
Scientific reports, 10(1), 19907-19907 (2020-11-18)
Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced

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