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S4641

Sigma-Aldrich

Sodium citrate tribasic dihydrate

ACS reagent, ≥99.0%

Synonym(s):

Citric acid trisodium salt dihydrate, Trisodium citrate dihydrate

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$52.70
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$74.70
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$273.00

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25 G
$36.50
500 G
$52.70
1 KG
$74.70
5 KG
$273.00

About This Item

Linear Formula:
HOC(COONa)(CH2COONa)2 · 2H2O
CAS Number:
Molecular Weight:
294.10
Beilstein/REAXYS Number:
6104939
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21
assay:
≥99.0%
grade:
ACS reagent
solubility:
water: soluble 29.4 g/L at 20 °C (completely)

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grade

ACS reagent

Quality Level

agency

suitable for SM 4500 - NH3

assay

≥99.0%

impurities

≤0.003% Ammonia (NH3)
≤0.005% Insoluble matter

pH

7.0-9.0 (25 °C, 5% in solution)

mp

>300 °C (lit.)

solubility

water: soluble 29.4 g/L at 20 °C (completely)

anion traces

chloride (Cl-): ≤0.003%
sulfate (SO42-): ≤0.005%

cation traces

Ca: ≤0.005%
Fe: ≤5 ppm
heavy metals: ≤5 ppm (by ICP-OES)

SMILES string

O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3

InChI key

NLJMYIDDQXHKNR-UHFFFAOYSA-K

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Application

Sodium citrate tribasic dihydrate can be used as a catalyst to synthesize:     
  • Fused O- and N-heterocyclic derivatives via multicomponent Knoevenagel-cyclocondensation of isatin/aldehyde/ acenaphthylene-1,2-dione, malononitrile, and various C−H activated acids.     
  • Chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidines by the condensation reaction of 4-hydroxycoumarin, aromatic aldehydes, and barbituric acid/thiobarbituric acid.

It can also be used as:      
A reducing agent to synthesize metal nanoparticles via sol-gel method using corresponding metal salt precursors.    
A controlling agent in the synthesis of single-crystal of coordination polymer [Co(H2O)2Ni(CN)4 4H2O].

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Mast cell (MC) deficiency in KitW-sh/W-sh mice and inhibition with disodium chromoglycate (DSCG) or ketotifen reduced obesity and diabetes in mice on a high-cholesterol (1.25%) Western diet. Yet, Kit-independent MC-deficient mice and mice treated with DSCG disproved MC function in
Ben Ouyang et al.
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Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of 0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only minor improvements. Here we discovered a dose threshold for improving nanoparticle tumour
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Nature communications, 11(1), 5239-5239 (2020-10-18)
The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand break (DSB) repair in cells deficient for NHEJ or homologous recombination, suggesting that it operates at all stages of the cell cycle. Here, we use an approach in which DNA breaks

Articles

Citrate is one of many cell culture components that affects the performance of serum-free, protein-free and animal protein-free cell culture systems used for biomanufacturing heterologous proteins such as monoclonal antibodies.

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This page is intended to make it easier to find the consumables you need based on the analytical method you’re using. Methods included on this page come from the EPA, Standard Methods and ASTM.

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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