PHR1152

Phenyl salicylate melting point standard

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Phenyl salicylate, Salol
• Linear Formula: 2-(HO)C₆H₄CO₂C₆H₅
• CAS Number: 118-55-8
• Molecular Weight: 214.22
• Beilstein/REAXYS Number: 393969
• EC Number: 204-259-2
• MDL number: MFCD00002213
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823170
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1534209
• API family: phenyl salicylate
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• bp: 172-173 °C/12 mmHg (lit.)
• mp: ~Approximately 42 °C; 41-43 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: Oc1ccccc1C(=O)Oc2ccccc2
• InChI: 1S/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H
• InChI key: ZQBAKBUEJOMQEX-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.

application

Phenyl salicylate may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7176 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H315,H317,H319,H411
• pcodes: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: 230.0 °F - closed cup
• flash_point_c: 110 °C - closed cup