44578

Dragendorff reagent

for TLC derivatization

• CAS Number: 39775-75-2
• MDL number: MFCD00283106
• UNSPSC Code: 12000000
• NACRES: NA.22

Properties

• grade: for TLC derivatization
• Quality Level: 100
• composition: acetic acid ; ethyl acetate ; sodium iodide ; sodium tetraiodobismutate
• technique(s): thin layer chromatography (TLC): suitable
• InChI: 1S/Bi.4HI.K/h;4*1H;/q+3;;;;;+1/p-4
• InChI key: ONBIUAZBGHXJDM-UHFFFAOYSA-J

Description

Application

• Nematocidal alkaloids from the roots of Stemona mairei: This study explores the use of Dragendorff reagent for the identification of nematocidal alkaloids, demonstrating its critical role in the pharmacological profiling and characterization of natural products (Shi et al., 2023).


• Rapid Detection and Determination of Scopolamine in Black Henbane: Leveraging Dragendorff reagent, this research developed a novel nanosensor for detecting scopolamine, an important application in pharmaceutical analysis and toxicology (Mousavizadeh et al., 2022).


• Proximate analysis and multi spectrometric analysis of Strychnos nux-vomica nuts: The use of Dragendorff reagent in the multi-spectrometric analysis highlights its versatility in chemical synthesis and compound identification, providing essential insights for medicinal chemistry (Ramachandran et al., 2022).


• TLC-MS identification of alkaloids in Leonuri Herba and Leonuri Fructus: This study used Dragendorff reagent to optimize a universal derivatization method, enhancing the detection and analysis of key pharmaceutical compounds in traditional medicine (Zhang et al., 2021).


• Densitometric TLC analysis for control of tropane and steroidal alkaloids in Lycium barbarum: Demonstrates the application of Dragendorff reagent in food chemistry for ensuring the safety and efficacy of herbal supplements through the precise detection of alkaloids (Kokotkiewicz et al., 2017).

Other Notes

This non-aqueous Thiess, Reuther and Vagujfalvi variant of the reagent is used to detect alkaloids and other nitrogen compounds in TLC

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225 - H314 - H336
• pcodes: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 44.6 °F
• flash_point_c: 7 °C
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter