31640

4,4′-Diaminodiphenylmethane

analytical standard

• Synonym(s): DAPM, 4,4′-Methylenedianiline, MDA
• Empirical Formula (Hill Notation): C₁₃H₁₄N₂
• CAS Number: 101-77-9
• Molecular Weight: 198.26
• Beilstein/REAXYS Number: 474706
• EC Number: 202-974-4
• MDL number: MFCD00007914
• UNSPSC Code: 41116107
• PubChem Substance ID: 329753859
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 88-92 °C
• application(s): cleaning products; cosmetics; food and beverages; personal care
• format: neat
• SMILES string: Nc1ccc(Cc2ccc(N)cc2)cc1
• InChI: 1S/C13H14N2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9,14-15H2
• InChI key: YBRVSVVVWCFQMG-UHFFFAOYSA-N

Description

General description

4,4′-Diaminodiphenylmethane (MDA) is an aromatic diamine, which finds industrial applications as a precursor in the manufacturing of polyurethane products, isocyanates, polyisocyanates, etc. It is also used as a hardener in the production of epoxy resins and elastomers.

4,4′-Diaminodiphenylmethane is a curing agent for epoxy resins. It is prepared from formaldehyde aniline when heated with aniline hydrochloride and aniline.

Application

4,4′-Diaminodiphenylmethane is used as an analytical reference standard for the quantification of the analyte in the following:

• Urine samples using gas-chromatography coupled to mass spectrometry (GC-MS).
• Hepatic microsomal incubation mixture from rabbits using high-performance liquid chromatography-plasma spray mass spectrometry (HPLC-PSP-MS), offline HPLC with fast atom bombardment mass spectrometry (FAB-MS) and fast atom bombardment tandem mass spectrometry (FAB-MS/MS).

It is reported to be used in the synthesis of amino modified multi-walled carbon nanotubes/polydimethylsiloxane, which serves as a coating for the stir bar sorptive extraction (SBSE) of phenols in environmental samples, followed by analysis using high performance liquid chromatography with ultraviolet detection (HPLC-UV).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H317,H341,H350,H370,H373,H410
• pcodes: P202 - P260 - P273 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 1B - Muta. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 1
• target_organs: Liver, Liver,eye - retina
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: 429.8 °F - closed cup
• flash_point_c: 221 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges