V-063

Pantothenic acid-¹³C₃,¹⁵N hemicalcium salt solution

100 μg/mL (90:10 Methanol:Water, (as free acid)), certified reference material, ampule of 1 mL, Cerilliant^®

• Empirical Formula (Hill Notation): ¹³C₃C₆H₁₆¹⁵NO₅ · 0.5Ca
• CAS Number: 356786-94-2
• Molecular Weight: 242.24
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL (90:10 Methanol:Water, (as free acid))
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C

Description

General description

An internal standard suitable for quantitation of pantothenic acid levels and testing applications including clinical and diagnostic testing or quality control testing of vitamin supplements, fortified foods or pharmaceutical preparations. Pantothenic acid, also known as Vitamin B5, is an essential water-soluble B vitamin that is involved in the coenzyme A (CoA) synthesis.

Application

• Enzyme inhibition studies: Stable isotope-labeled pantothenic acid is used in X-ray crystallography and NMR studies to understand the mechanism of homotropic inhibition in enzyme reactions, specifically pantothenate synthetase. Such studies are essential for drug design targeting metabolic pathways, enhancing the effectiveness of treatments involving vitamin B5 pathways (Chakrabarti et al., 2010).


• NMR structural analysis: The labeled compound aids in the NMR structural elucidation of enzymes such as ketopantoate reductase, helping to determine its role in biological systems. This analysis is crucial for developing drugs that can manipulate these enzymatic pathways, impacting treatments for conditions requiring metabolic modulation (Headey et al., 2008).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P302 + P352 + P312 - P304 + P340 + P311 - P370 + P378 - P403 + P235
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup