C-059
Clozapine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
InChI
1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
QZUDBNBUXVUHMW-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813) , HTR2A(3356)
General description
A Certified Snap-N-Spike® Solution for use in clinical toxicology, forensic analysis, or urine drug testing applications by LC/MS or GC/MS. Clozapine, sold as Clozaril® and FazaClo® in the US, is an atypical antipsychotic drug used for treatment of schizophrenia.
Application
- Augmentation Strategies for Clozapine Non-responders: A Bayesian network meta-analysis evaluated augmentation strategies for patients with schizophrenia who show partial or no response to clozapine, providing insights into effective secondary treatment options (Mishra et al., 2024).
- Antipsychotic Pre-treatment and Clozapine Metabolism: Research highlighted the impact of rapid metabolism of antipsychotics prior to clozapine treatment, affecting serum levels and suggesting a need for adjusted dosing strategies in treatment-resistant schizophrenia (Lenk HÇ et al., 2024).
- Genetic Influences on Clozapine Side Effects: A study identified polymorphisms in ERBB4 and TACR1 genes associated with dry mouth in patients treated with clozapine, pointing towards personalized management strategies for side effects (Puolakka et al., 2024).
- Therapeutic Mechanisms of Antipsychotics: An analysis focused on understanding the therapeutic mechanisms of antipsychotics including clozapine, examining cellular and molecular targets and their implications for optimizing treatment efficacy in psychiatric disorders (Direktor et al., 2024).
- Clozapine and Metabolic Syndrome in Schizophrenia: A study assessed the association between cytokine levels, psychopathology, and cognitive functions in clozapine-treated schizophrenia patients with metabolic syndrome, providing data critical for holistic treatment approaches (Dong et al., 2024).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificates of Analysis (COA)
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