870865P
Avanti
BMP22
Avanti Research™ - A Croda Brand, powder
Synonym(s):
4-pentadecylbenzylphosphonic acid
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About This Item
Empirical Formula (Hill Notation):
C22H39O3P
CAS Number:
Molecular Weight:
382.52
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
assay
99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (870865P-1mg)
pkg of 1 × 5 mg (870865P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1
InChI key
XWVBRTAQHMKHCE-UHFFFAOYSA-N
General description
BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.
Biochem/physiol Actions
BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.
Packaging
5ML Glass Amber Screw Cap Vial (870865P-1MG)
5ML Glass Amber Screw Cap Vial (870865P-5MG)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh M, et al.
Biochemical Society Transactions, 40(1), 31-36 (2012)
Bis (monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Anderson DMG, et al.
Scientific Reports, 7(1), 17352-17352 (2017)
Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss
Flammier S, et al.
Arthritis and Rheumatism (2019)
Transacylase formation of bis (monoacylglycerol) phosphate
Heravi J and Waite M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1437(3), 277-286 (1999)
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