860692P
Avanti
C16:0 Ceramide (d18:2(4E,8Z)/16:0)
Avanti Research™ - A Croda Brand 860692P, powder
Synonym(s):
N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base)
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About This Item
Empirical Formula (Hill Notation):
C34H65NO3
CAS Number:
Molecular Weight:
535.88
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 1 mg (860692P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860692P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@@](NC(CCCCCCCCCCCCCCC)=O)([H])[C@]([H])(O)/C=C/CC/C=C\CCCCCCCCC
General description
C16:0 Ceramide (d18:2(4E,8Z)/16:0) or N-palmitoyl-D-erythro-sphingosine (d18:2(4E,8Z) base) is a long chain ceramide derived from sphingosine containing two double bonds with palmitic acid. C16:0 Ceramide synthesis is catalyzed by the enzyme ceramide synthase 6 (CerS6).
Biochem/physiol Actions
C16:0-ceramide facilitates obesity-related insulin resistance. It exhibits pro-apoptotic function. Elevated levels of C16:0-ceramide has been observed in adipose tissue of obese patients.
Packaging
5 mL Amber Glass Screw Cap Vial (860692P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Certificates of Analysis (COA)
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Sarah M Turpin et al.
Cell metabolism, 20(4), 678-686 (2014-10-09)
Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6). It remains unresolved whether obesity-associated alterations of specific CerSs and their defined acyl-chain length
Timothy Hla et al.
Cell metabolism, 20(5), 703-705 (2014-12-03)
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related
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