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810131C

Avanti

16:0-12:0 NBD PC

Avanti Research™ - A Croda Brand 810131C

Synonym(s):

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C42H74N5O11P
CAS Number:
105539-26-2
Molecular Weight:
856.04
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810131C-1mg)
pkg of 5 × 1 mL (810131C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810131C

concentration

1 mg/mL (810131C-1mg)
1 mg/mL (810131C-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylcholine (PC) is a common phospholipid found in eukaryotes and a prime metabolite of glycerolipid metabolism. It is a vital component of the mucosal layer of the colon. NBD PC is a fluorescently labeled lipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to phosphatidylcholine.

Application

16:0-12:0 NBD PC has been used as a fluorescent marker to study the adsorption of hyaluronan (HA) onto a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer deposited on a silica surface by fluorescent microscopy. It may also be used:
  • in the microfluidic chip-based technology to demonstrate separation of fluorophore-labeled phospholipids and to monitor enzyme activities of lipid-modifying enzymes
  • as a fluorophore for DPPC in fluorescence recovery experiments
  • as a substrate to test scramblase activity

Biochem/physiol Actions

7-nitrobenz-2-oxa-1,3-diazol-4-yl phosphatidylcholine (NBD PC) is useful in the study of cellular processes as it functions as a fluorescent analog in lipid membranes and phospholipid phase transitions.

Packaging

5 mL Amber Glass Screw Cap Vial (810131C-1mg)
5 mL Amber Glass Screw Cap Vial (810131C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk_germany

WGK 3

Certificates of Analysis (COA)

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The diffusion law of DMPC and DPPC in Supported Lipid Bilayers (SLB), on different substrates, has been investigated in details by Fluorescence Recovery After Patterned Photobleaching (FRAPP). Over micrometer length scales, we demonstrate the validity of a purely Brownian diffusive
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Physical chemistry chemical physics : PCCP, 22(11), 6154-6166 (2020-03-04)
The antibacterial activity of a calixarene derivative, p-tert-butylcalix[6]arene (Calix6), was assessed and was shown not to inhibit the growth of E. coli, S. aureus and B. subtilis bacteria. With the aim of gaining more insights into the absence of antibacterial
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Langmuir : the ACS journal of surfaces and colloids, 35(47), 15232-15241 (2019-11-09)
Matrix vesicles (MVs) are a special class of extracellular vesicles that drive bone and dentin mineralization by providing the essential enzymes and ions for the nucleation and propagation of mineral crystals. Tissue-nonspecific alkaline phosphatase (TNAP) is an integral protein of
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The Journal of biological chemistry, 282(11), 8498-8509 (2007-01-19)
Macrophage recognition of apoptotic cells depends on externalization of phosphatidylserine (PS), which is normally maintained within the cytosolic leaflet of the plasma membrane by aminophospholipid translocase (APLT). APLT is sensitive to redox modifications of its -SH groups. Because activated macrophages
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