700172P
Avanti
cholesterol-d6
Avanti Research™ - A Croda Brand, powder
Synonym(s):
cholesterol-d6
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About This Item
Empirical Formula (Hill Notation):
C27H40D6O
CAS Number:
Molecular Weight:
392.69
UNSPSC Code:
41141804
NACRES:
NA.25
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700172P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Cholesterol-d6 is a deuterium labelled cholesterol. Ring labelled D6-cholesterol forms D6-steroidal glycoalkaloids (SGA).
Cholesterol-d6 is the deuterated cholesterol with deuteration in ring.
Application
Cholesterol-d6 is suitable for its use as a synthetic lipid standard, for cholesterol determination.
Cholesterol-d6 is used as a standard to detect cholesterol concentration using chromatography technique. It is also used to measure the percentage of cholesterol absorption by intravenously administrating into experimental animals.
Cholesterol-d6 may be used as an internal standard in
- electrospray ionization tandem mass spectrometry (ESIMS/MS)
- gas chromatography–mass spectrometry (GC-MS)
- for spiking lipid extracts from Drosophila for liquid chromatography–mass spectrometry (LC-MS)
Biochem/physiol Actions
Cholesterol-d6 rich liposomes are used in understanding the kinetics of reverse cholesterol transport in lymphatic and aorta. It is used in the generation of stratum corneum (SC) lipid model systems for deuteration based neutron diffraction studies. Use of Cholesterol-d6 as a diet supplement has enabled the understanding cholesterol metabolism in the blood brain barrier.
Packaging
5 mL Amber Glass Screw Cap Vial (700172P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes
Fredericks WJ, et al.
Testing, 4(7), 1075-1075 (2013)
Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain
Saeed AA, et al.
The Journal of Biological Chemistry, 289(34), 23712-23722 (2014)
Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue
Bonzon-Kulichenko E, et al.
Endocrinology, 150(1), 169-178 (2008)
Perdeuteration of cholesterol for neutron scattering applications using recombinant Pichia pastoris
Moulin M, et al.
Chemistry and Physics of Lipids, 212, 80-87 (2018)
Biochemical membrane lipidomics during Drosophila development
Guan XL, et al.
Developmental Cell, 24(1), 98-111 (2013)
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