3-Methyl-6-propargyl-1,4-dioxane-2,5-dione is a functionalized biodegradable monomer that can be polymerized using ring-opening polymerization to yield polylactide with a pendant alkyne functionality. This pendant group can be used to further functionalize the polymer or as a backbone for graft copolymer synthesis.
″Clickable″ Polyglycolides: Tunable Synthons for Thermoresponsive, Degradable Polymers.
Jiang X, et al.
Macromolecules, 41(6), 1937-1944 (2008)
Functional Polylactide-g-Paclitaxel-Poly(ethylene glycol) by Azide-Alkyne Click Chemistry.
Yu Y, et al.
Macromolecules, 44(12), 4793-4800 (2011)
Synthesis and ring-opening polymerisation of a newalkyne-functionalised glycolide towards biocompatible amphiphilic graft copolymers.
Coumes F, et al.
Polym. Chem., 4, 3705-3713 (2013)
A degradable brush polymer-drug conjugate for pH-responsive release of doxorubicin.
Yu Y, et al.
Polym. Chem., 6, 953-961 (2015)
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