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779431
γ-Cyclodextrin
produced by Wacker Chemie AG, Burghausen, Germany, ≥90.0% cyclodextrin basis (HPLC)
Synonym(s):
Cavamax® W8, gamma-Cyclodextrin, Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin
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100 G
$170.00
1 KG
$398.00
About This Item
Empirical Formula (Hill Notation):
C48H80O40
CAS Number:
Molecular Weight:
1297.12
Beilstein/REAXYS Number:
78740
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.22
form:
powder
assay:
≥90.0% cyclodextrin basis (HPLC)
Recommended Products
grade
produced by Wacker Chemie AG, Burghausen, Germany
Quality Level
assay
≥90.0% cyclodextrin basis (HPLC)
form
powder
loss
≤11.0% loss on drying
functional group
ether
hydroxyl
SMILES string
[H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O
InChI
1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1
InChI key
GDSRMADSINPKSL-HSEONFRVSA-N
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General description
Gamma-cyclodextrin (γ-CD) is a cyclic α-1,4-glucan linked oligosaccharide that is widely used in the food and pharmaceutical industries. In drug delivery, γ-CD can be used as a complexing agent because it forms an inclusion complex with a drug molecule. The complex of cyclodextrin increases the aqueous solubility and dissolution rate of the drug, which is useful for the delivery of the medical agent to a biological system.[1][2]
Application
γ-Cyclodextrin can be used as a precursor for the synthesis of:
- Octakis-(2,3-di-O-methyl-6-O-carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). ODMCM is used in capillary electrophoresis as a chiral resolving agent.[3]
- Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs.[4]
Legal Information
Cavasol is a registered trademark of Wacker Chemie AG
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs
Becker LF, et al.
Beilstein Journal of Organic Chemistry, 10(1), 2920-2927 (2014)
Safety assessment of γ-cyclodextrin
Munro IC, et al.
Regulatory Toxicology and Pharmacology, 39, 3-13 (2004)
Single-isomer carboxymethyl-γ-cyclodextrin as chiral resolving agent for capillary electrophoresis
Benkovics G, et al.
Journal of Chromatography A, 1467(2), 445-453 (2016)
γ-Cyclodextrin: a review on enzymatic production and applications.
Li, Zhaofeng et al.
Applied Microbiology and Biotechnology, 77(2), 245-245 (2007)
Takaaki Harada et al.
The journal of physical chemistry. B, 115(5), 1268-1274 (2011-01-05)
Diamide linked γ-cyclodextrin (γ-CD) dimers are used to capture curcumin and suppress its decomposition in water. In this study, succinamide and urea linked γ-CD dimers joined through the C6(A) carbon on each γ-CD are used. The γ-CD dimers, 66γCD(2)su and
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