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527742

Sigma-Aldrich

2-Cyanobenzoic acid

technical grade

Synonym(s):

o-Carboxybenzonitrile, NSC 193443

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About This Item

Linear Formula:
NCC6H4CO2H
CAS Number:
3839-22-3
Molecular Weight:
147.13
MDL number:
MFCD00045796
UNSPSC Code:
12352100
PubChem Substance ID:
24874642
NACRES:
NA.22

grade

technical grade

form

solid

mp

212 °C (lit.)

SMILES string

OC(=O)c1ccccc1C#N

InChI

1S/C8H5NO2/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4H,(H,10,11)

InChI key

DTNSDCJFTHMDAK-UHFFFAOYSA-N

General description

2-Cyanobenzoic acid can be prepared from phthalic anhydride. Mass spectrophotometry, NMR, IR are extremely useful techniques to determine the ring-chain tautomeric equilibrium of 2-cyanobenzoic acid in all three phases. The standard (p° = 0.1MPa) molar enthalpy of formation of 2-cyanobenzoic acid is -(150.7 ± 2.0) kJ.mol-1.

Application

2-Cyanobenzoic acid may be used to synthesize phthalamidine.
Reactant involved in the synthesis of:
  • T-box riboswitch antiterminator RNA-binding oxazolidinone derivatives
  • Benzoate modified β-cyclodextrin derivatives
  • Pyrrolo[1,2-f]triazines for use as JAK2 inhibitors

Reactant involved in:
  • Decarboxylation
  • Decarboxylative halogenation
  • Protodecarboxylation

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Experimental Study of Tautomeric Equilibria of 2-Cyanobenzoic Acids in Gas, Solution and Solid Phase.
Iglesias DA, et al.
Journal of Applied Solution Chemistry and Modeling, 1(2), 113-113 (2012)
The Study of Novel Synthetic Method of 2-Cyanobenzo.
Yang YS, et al.
Guangzhou Chemical Industry/ Guangzhou Huagong, 22, 016-016 (2011)
Standard molar enthalpies of formation of 2-, 3-and 4-cyanobenzoic acids.
da Silva MAVR, et al.
The Journal of Chemical Thermodynamics, 40(8), 1226-1231 (2008)
Studies on the syntheses of heterocyclic compounds. CCIV. Ring contraction in the catalytic hydrogenation of 3-oximino-4-oxoisocarbostyril.
Kametani T, et al.
Chemical & Pharmaceutical Bulletin, 15(12), 1916-1921 (1967)

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