363340

N-Acetylcysteamine

95%

• Synonym(s): N-(2-Mercaptoethyl)acetamide
• Linear Formula: CH₃CONHCH₂CH₂SH
• CAS Number: 1190-73-4
• Molecular Weight: 119.19
• MDL number: MFCD00037831
• UNSPSC Code: 12352100
• eCl@ss: 32160406
• PubChem Substance ID: 24862192
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 95%
• form: liquid
• refractive index: n20/D 1.511 (lit.)
• bp: 138-140 °C/7 mmHg (lit.)
• mp: 6-7 °C (lit.)
• density: 1.121 g/mL at 25 °C (lit.)
• SMILES string: CC(=O)NCCS
• InChI: 1S/C4H9NOS/c1-4(6)5-2-3-7/h7H,2-3H2,1H3,(H,5,6)
• InChI key: AXFZADXWLMXITO-UHFFFAOYSA-N

Description

General description

N-Acetylcysteamine, also known as N-(2-Mercaptoethyl) acetamide, is a derivative of cysteamine, that is commonly used as a building block for the synthesis of alkylated thiol and thioesters via esterification.

Application

N-Acetylcysteamine can be used as a building block to synthesize:

• N

• -acetylcysteamine (SNAC) thioesters by reacting with various acid derivatives in the presence of 1,1′-carbonyldiimidazole (CDI).      
• Thieno[2,3-c]pyrrole derivatives via three-component reaction of 2-acetyl-3-thiophenecarboxaldehyde and various amines.
•  Carbapenems, a class of beta-lactam antibiotic agents.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter