346675

5-Acetylsalicylamide

98%

• Synonym(s): 5-Acetyl-2-hydroxybenzamide
• Linear Formula: CH₃COC₆H₃(OH)CONH₂
• CAS Number: 40187-51-7
• Molecular Weight: 179.17
• EC Number: 254-830-5
• MDL number: MFCD00049222
• UNSPSC Code: 12352100
• PubChem Substance ID: 24861425

Properties

• assay: 98%
• mp: 220-222 °C (lit.)
• SMILES string: CC(=O)c1ccc(O)c(c1)C(N)=O
• InChI: 1S/C9H9NO3/c1-5(11)6-2-3-8(12)7(4-6)9(10)13/h2-4,12H,1H3,(H2,10,13)
• InChI key: LWAQTCWTCCNHJR-UHFFFAOYSA-N

Description

General description

5-Acetylsalicylamide is formed by lewis acidic ionic liquid catalyzed Friedel-Crafts acylation of salicylamide with acetyl chloride.

Application

5-Acetylsalicylamide can be used in the preparation of 5-acetyl-2(3H)-benzoxazolone, via two-step synthetic route using Hofmann rearrangement.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves