344249

Diphenyl phosphoryl chloride

96%

• Synonym(s): Diphenyl chlorophosphate, Diphenyl phosphorochloridate
• Linear Formula: (C₆H₅O)₂POCl
• CAS Number: 2524-64-3
• Molecular Weight: 268.63
• Beilstein/REAXYS Number: 654130
• EC Number: 219-759-6
• MDL number: MFCD00003030
• UNSPSC Code: 12352100
• PubChem Substance ID: 24861235
• NACRES: NA.22

Properties

• vapor pressure: 10 mmHg ( 190 °C)
• assay: 96%
• form: liquid
• refractive index: n20/D 1.55 (lit.)
• bp: 314-316 °C/272 mmHg (lit.)
• density: 1.296 g/mL at 25 °C (lit.)
• SMILES string: ClP(=O)(Oc1ccccc1)Oc2ccccc2
• InChI: 1S/C12H10ClO3P/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H
• InChI key: BHIIGRBMZRSDRI-UHFFFAOYSA-N

Description

General description

Diphenyl phosphoryl chloride is a diaryl phosphoryl derivative. It is formed during the preparation of monophenyl phosphoryl chloride via reaction of phenol and phosphorus oxychloride.

Application

Diphenyl phosphoryl chloride may be used:

• in the preparation of guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate
• as phosphorylating agent for the synthesis of 2-deoxy-D-galactose-3 and -6 phosphoric acids
• in the synthesis of diaryl phosphoryl derivatives of alkylene dithiophosphates

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314
• pcodes: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: >235.4 °F - closed cup
• flash_point_c: > 113 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter