247898

Isosorbide dimethyl ether

98%

• Synonym(s): DMI, Dimethyl isosorbide, 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol, 1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether, 2,5-Di-O-methyl-1,4:3,6-dianhydro-D-glucitol
• Empirical Formula (Hill Notation): C₈H₁₄O₄
• CAS Number: 5306-85-4
• Molecular Weight: 174.19
• Beilstein/REAXYS Number: 80854
• EC Number: 226-159-8
• MDL number: MFCD00064828
• UNSPSC Code: 12352005
• PubChem Substance ID: 24854898
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• form: liquid
• optical activity: [α]21/D +96.1°, c = 2 in chloroform
• refractive index: n20/D 1.461 (lit.)
• bp: 93-95 °C/0.1 mmHg (lit.)
• density: 1.15 g/mL at 25 °C (lit.)
• SMILES string: CO[C@H]1COC2[C@@H](COC12)OC
• InChI: 1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1
• InChI key: MEJYDZQQVZJMPP-ULAWRXDQSA-N

Description

Application

Isosorbide dimethyl ether (DMI), a sustainable solvent, is widely used in various cosmetic and pharmaceutical formulations.[1]
General applications:

• DMI can be used as an alternative green solvent for epoxidation of cyclooctene[2], Baylis–Hillman reaction of isomaltulose-derived aldehydes with α,β-unsaturated ketones[3] and also in solid-phase synthesis.[4]
• It can be used as a coalescent for water-borne paints, where it acts as a co-solvent during the water loss phase and as a coalescing agent during the film formation.[5]

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 240.8 °F - closed cup
• flash_point_c: 116 °C - closed cup
• ppe: Eyeshields, Gloves