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152935

Sigma-Aldrich

1-Piperidinepropanol

97%

Synonym(s):

1-(3-Hydroxypropyl)piperidine

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About This Item

Empirical Formula (Hill Notation):
C8H17NO
CAS Number:
104-58-5
Molecular Weight:
143.23
EC Number:
203-216-5
MDL number:
MFCD00023781
UNSPSC Code:
12352100
PubChem Substance ID:
24849267
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.4775 (lit.)

bp

94-95 °C/0.5 mmHg (lit.)

density

0.944 g/mL at 25 °C (lit.)

SMILES string

OCCCN1CCCCC1

InChI

1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2

Inchi Key

PLRXAFVBCHEMGD-UHFFFAOYSA-N

Application

1-Piperidinepropanol was used to prepare isothiourea.
Reactant in:
Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions
Suzuki-coupling

Reactant for synthesis of:
Histamine H3 receptor antagonists
Protein lysine methyltransferase G9a inhibitors
Serotonin-4 receptors antagonists
Checkpoint kinase Chk2 inhibitors

Pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

208.0 °F - closed cup

flash_point_c

97.8 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shinya Harusawa et al.
Bioorganic & medicinal chemistry letters, 23(23), 6415-6420 (2013-10-22)
S-Alkyl-N-alkylisothiourea compounds containing various cyclic amines were synthesized in the search for novel nonimidazole histamine H3 receptor (H3R) antagonists. Among them, four N-alkyl S-[3-(piperidin-1-yl)propyl]isothioureas 18, 19, 22, and 23 were found to exhibit potent and selective H3R antagonistic activities against
Joseph A McQuail et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(50), 12537-12548 (2016-11-04)
Working memory, the ability to temporarily maintain representational knowledge, is a foundational cognitive process that can become compromised in aging and neuropsychiatric disease. NMDA receptor (NMDAR) activation in prefrontal cortex (PFC) is necessary for the pyramidal neuron activity believed to

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