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134708

Sigma-Aldrich

2-Bromo-2-nitro-1,3-propanediol

98%

Synonym(s):

BNPD, BNPK, Bronopol

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About This Item

Linear Formula:
HOCH2C(Br)(NO2)CH2OH
CAS Number:
52-51-7
Molecular Weight:
199.99
Beilstein/REAXYS Number:
1705868
EC Number:
200-143-0
MDL number:
MFCD00007390
UNSPSC Code:
12352100
PubChem Substance ID:
24848173
NACRES:
NA.22

assay

98%

form

crystals

mp

130-133 °C (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to faintly yellow

SMILES string

OCC(Br)(CO)[N+]([O-])=O

InChI

1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2

InChI key

LVDKZNITIUWNER-UHFFFAOYSA-N

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Application

  • Effect of leave-on cosmetic antimicrobial preservatives on healthy skin resident Staphylococcus epidermidis.: This study examines the impact of various antimicrobial preservatives, including 2-Bromo-2-nitro-1,3-propanediol, on the microbiota of healthy skin, particularly focusing on Staphylococcus epidermidis. The findings suggest that such preservatives can influence the skin′s microbial balance, which is essential for maintaining skin health (Zhang et al., 2023).
  • Assessing the residual antibacterial activity of clinical materials disinfected with glutaraldehyde, o-phthalaldehyde, hydrogen peroxide or 2-bromo-2-nitro-1,3-propanediol by means of a bacterial toxicity assay.: This research assesses the residual antibacterial effects of various disinfectants, including 2-Bromo-2-nitro-1,3-propanediol, on clinical materials, contributing to improved disinfection protocols in healthcare settings (Lerones et al., 2004).
  • Development and testing of a microbiological assay to detect residual effects of disinfectant on hard surfaces.: This study developed a microbiological assay to evaluate the residual effects of disinfectants, including 2-Bromo-2-nitro-1,3-propanediol, on hard surfaces, aiming to enhance surface disinfection strategies in various industries (Mariscal et al., 1999).

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

4.1B - Flammable solid hazardous materials

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

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2-Bromo-2-nitro-1, 3-propanediol (Bronopol) and its derivatives: Synthesis, properties, and application (a review).
Legin, G. Ya.
Pharmaceutical Chemistry Journal, 30(4), 273-284 (1996)
Mustapha Kireche et al.
Contact dermatitis, 63(4), 192-202 (2010-08-25)
Compounds slowly releasing formaldehyde, the so-called formaldehyde-releasers, are commonly employed as preservatives in cosmetics instead of free formaldehyde, which is a strong skin sensitizer. It has been long accepted that formaldehyde-releaser sensitization is attributable to released formaldehyde. However, clinical studies
Mustapha Kireche et al.
Chemical research in toxicology, 24(12), 2115-2128 (2011-11-01)
Formaldehyde and formaldehyde releasers are widely used preservatives and represent an important group of skin sensitizers. Formaldehyde is very often suspected to be the sensitizing agent of formaldehyde-releasers; however, many reported clinical cases of contact allergy to these molecules such
C Lerones et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 10(11), 984-989 (2004-11-04)
This study investigated the use of a rapid bacterial toxicity test for detecting disinfectant residues released by disinfected materials. The test substances included an environmental disinfectant used in hospitals in high-risk areas, such as critical care units or emergency services
A Sánchez et al.
Journal of dairy science, 90(7), 3153-3161 (2007-06-22)
The aim of this research was to evaluate the Milko-Scan FT 6000 (Foss Electric, Hillerød, Denmark) for determining the freezing point (FP) of goat's milk under different analytical conditions. The FP was determined in duplicate in 1,800 milk aliquots obtained
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