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123129

Sigma-Aldrich

2-Aminothiazole

97%

Synonym(s):

2-Thiazolamine

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5 G
$31.00
100 G
$58.90
500 G
$134.00

About This Item

Empirical Formula (Hill Notation):
C3H4N2S
CAS Number:
96-50-4
Molecular Weight:
100.14
Beilstein/REAXYS Number:
105738
EC Number:
202-511-6
MDL number:
MFCD00005325
UNSPSC Code:
12352100
PubChem Substance ID:
24847523
NACRES:
NA.22

$31.00

Available to ship onMay 02, 2025Details

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assay

97%

mp

91-93 °C (lit.)

solubility

1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)

SMILES string

Nc1nccs1

InChI

1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)

InChI key

RAIPHJJURHTUIC-UHFFFAOYSA-N

Application

2-Aminothiazole was used in the synthesis of 2-aminothiazole-modified silica gel[1]. It was used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation[2].

Biochem/physiol Actions

2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders[3].

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB1324
STBL1363
STBL2823
STBL1721
STBL0203

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Synthetic Communications, 37, 1853-1853 (2007)
Xin Cao et al.
Bioorganic & medicinal chemistry, 16(11), 5890-5898 (2008-05-20)
Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heteroarylamino-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, prepared, and evaluated for blocking multiple signaling pathways in cancer therapy. All compounds were evaluated
Christopher J Helal et al.
Bioorganic & medicinal chemistry letters, 14(22), 5521-5525 (2004-10-16)
High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC(50)=ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the
P S Roldan et al.
Analytical and bioanalytical chemistry, 375(4), 574-577 (2003-03-01)
This work describes the synthesis and characterization of 2-aminothiazole-modified silica gel (SiAT), as well as its application for preconcentration (in batch and column technique) of Cu(II), Ni(II) and Zn(II) in ethanol medium. The adsorption capacities of SiAT determined for each
Raju Subramanian et al.
Chemical research in toxicology, 23(3), 653-663 (2010-01-26)
A 2-aminothiazole derivative 1 was developed as a potential inhibitor of the oncology target AKT, a serine/threonine kinase. When incubated in rat and human liver microsomes in the presence of NADPH, 1 underwent significant metabolic activation on its 2-aminothiazole ring
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Questions

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    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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