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Sigma-Aldrich

Tetramethylthiourea

98%

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About This Item

Linear Formula:
(CH3)2NCSN(CH3)2
CAS Number:
Molecular Weight:
132.23
Beilstein/REAXYS Number:
1744916
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

98%

form

solid

bp

245 °C (lit.)

mp

75-77 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C)C(=S)N(C)C

InChI

1S/C5H12N2S/c1-6(2)5(8)7(3)4/h1-4H3

InChI key

MNOILHPDHOHILI-UHFFFAOYSA-N

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General description

Tetramethylthiourea molecule shows crystallographic two-fold symmetry with weak hydrogen bond packing, which connects the molecules to form layers.

Application

Tetramethylthiourea forms BF3 adduct with tetramethylselenourea.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Jiqin Liu et al.
Molecular immunology, 45(15), 3984-3989 (2008-07-29)
N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC
[Effect of thyroid deficiency on cutaneous nerve development in chickens].
R Saxod et al.
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 294(1), 19-24 (1982-01-04)
T Sakamoto et al.
The American journal of physiology, 276(6 Pt 1), C1391-C1397 (1999-06-11)
Obesity is associated with hyperinsulinemia and elevated concentrations of tumor necrosis factor-alpha (TNF-alpha) in adipose tissue. TNF-alpha has been implicated as an inducer of the synthesis of plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of fibrinolysis, mediated by plasminogen
Alexius Freyberger et al.
Toxicology, 217(2-3), 169-175 (2005-11-22)
N,N,N',N'-Tetramethylthiourea (TMTU) is a rat goitrogen inducing thyroid hyperplasia, hypertrophy, and tumor formation. Little is known about the exact underlying mechanism of action. As thyroid peroxidase (TPO) and type I iodothyronine deiodinase (ID-I) have been established as targets of goitrogenic
Allen Mambanda et al.
Dalton transactions (Cambridge, England : 2003), 39(15), 3595-3608 (2010-04-01)
The rate of displacement of the aqua ligands by three neutral nucleophiles (Nu) of different steric demands, namely thiourea (tu), N,N'-dimethylthiourea (dmtu) and N,N,N',N'-tetramethylthiourea (tmtu) and an anionic nucleophile (I(-)) in complexes of the form [{Pt(H(2)O)}(2)(N,N,N',N'-tetrakis(2-pyridylmethyl)-N(CH(2))(n)N](CF(3)SO(3))(4), n = 2 (En);

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