SPANXB1
SPANX family, member B1
Synonyms:
B1, CT11.2, SPANX-B, SPANXB
Species:
UniProtKB ID:
Gene ID:
- Human(728695) Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPANXB1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-SPANXB1 antibody produced in mouse, clone 2E12, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
esiRNA
Product Number
Description
Species