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PVRL1

poliovirus receptor-related 1 (herpesvirus entry mediator C)

Synonyms:
CD111, CLPED1, ED4, HIgR, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1
Species:
UniProtKB ID:
Gene ID:
  • Human(5818) Summary: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
  • Mouse(58235) poliovirus receptor-related 1
  • Rat(192183) poliovirus receptor-related 1
  • dog(489363) poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • domestic cat(101098252) poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • domestic guinea pig(100724766) poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • naked mole-rat(101713982) poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • cow(533492) poliovirus receptor-related 1 (herpesvirus entry mediator C)
  • sheep(101116172) poliovirus receptor-related 1 (herpesvirus entry mediator C)

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human Nectin-1 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NECTIN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PVRL1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
Anti-PVRL1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PVRL1 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot
Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302, clone R1.302.12, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NECTIN1,
Species
human
MISSION® esiRNA, targeting mouse Pvrl1,
Species
mouse