GAD1
glutamate decarboxylase 1 (brain, 67kDa)
Synonyms:
CPSQ1, GAD, SCP
Species:
Human GAD1 (2571), Mouse Gad1 (14415), Rat Gad1 (24379), sheep GAD1 (101117393), domestic cat GAD1 (493699), domestic guinea pig Gad1 (100271904), naked mole-rat Gad1 (101725846), cow GAD1 (517552), fruit fly Gad1 (38484), chicken GAD1 (395743)
UniProtKB ID:
Gene ID:
- Human(2571) Summary: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
- Mouse(14415) glutamate decarboxylase 1
- Rat(24379) glutamate decarboxylase 1
- sheep(101117393) glutamate decarboxylase 1 (brain, 67kDa)
- domestic cat(493699) glutamate decarboxylase 1 (brain, 67kDa)
- domestic guinea pig(100271904) glutamate decarboxylase 1
- naked mole-rat(101725846) glutamate decarboxylase 1 (brain, 67kDa)
- cow(517552) glutamate decarboxylase 1 (brain, 67kDa)
- fruit fly(38484) Glutamic acid decarboxylase 1
- chicken(395743) glutamate decarboxylase 1 (brain, 67kDa)
- dog(478794) glutamate decarboxylase 1 (brain, 67kDa)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GAD67/GAD1 Antibody, clone 4I8S8, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-GAD67 Antibody, clone 1G10.2, clone 1G10.2, Chemicon®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-GAD67 Antibody, clone 1G10.2, Biotin Conjugate, clone 1G10.2, from mouse, biotin conjugate,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunohistochemistry
Anti-GAD67 Antibody, clone 1G10.2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-GAD1 antibody produced in mouse, clone 5E11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot