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DUX4

double homeobox 4

Synonyms:
DUX10
Species:
Human DUX4 (22947), dog DUX4 (491532)
UniProtKB ID:
Q9UBX2
Gene ID:
  • Human(22947) Summary: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of this gene from standard cDNA libraries, however, RT-PCR and in vitro expression experiments indicate that the ORF is transcribed. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, May 2013]
  • dog(491532) uncharacterized LOC491532

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB5200019
Monoclonal Anti-DUX4 antibody produced in mouse, clone P2B1, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
HPA058451
Anti-DUX4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
MABS1348
Anti-DUX4 Antibody, clone P4H2, clone P4H2, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
MABD116
Anti-Dux4 Antibody, clone 9A12, clone 9A12, from mouse,
Species Reactivity
human
Application
electrophoretic mobility shift assay
immunocytochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
EHU904471
MISSION® esiRNA, targeting human DUX4,
Species
human