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41525

Sigma-Aldrich

N,N-Dimethyl-6-propionyl-2-naphthylamine

BioReagent, suitable for fluorescence, ≥98.0% (HPLC)

Synonym(s):

2-(Dimethylamino)-6-propionylnaphthalene, 6-Propionyl-2-(dimethylamino)naphthalene, Prodan

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About This Item

Empirical Formula (Hill Notation):
C15H17NO
CAS Number:
70504-01-7
Molecular Weight:
227.30
Beilstein:
2723587
MDL number:
MFCD00056615
UNSPSC Code:
12352116
PubChem Substance ID:
57650063
NACRES:
NA.32

product line

BioReagent

Quality Level

100

Assay

≥98.0% (HPLC)

form

solid

mp

137 °C (lit.)

solubility

DMF: soluble
acetone: soluble
acetonitrile: soluble
methanol: soluble

fluorescence

λex 361 nm; λem 498 nm in methanol

suitability

suitable for fluorescence

SMILES string

CCC(=O)c1ccc2cc(ccc2c1)N(C)C

InChI

1S/C15H17NO/c1-4-15(17)13-6-5-12-10-14(16(2)3)8-7-11(12)9-13/h5-10H,4H2,1-3H3

InChI key

MPPQGYCZBNURDG-UHFFFAOYSA-N

Related Categories

Application

N,N-Dimethyl-6-propionyl-2-naphthylamine (Prodan), a membrane surface probe, may be used as a fluorescence probe in non-cell based in vitro assay for the determination of drug-phospholipid complex formation and to study membrane surface properties.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Fluorescence of spectrin-bound Prodan

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Paul Abbyad et al.
The journal of physical chemistry. B, 111(28), 8269-8276 (2007-06-27)
Proteins respond to electrostatic perturbations through complex reorganizations of their charged and polar groups, as well as those of the surrounding media. These solvation responses occur both in the protein interior and on its surface, though the exact mechanisms of
Masaki Goto et al.
Biophysical chemistry, 231, 64-70 (2017-04-16)
The phase transitions of N-methylated di-O-hexadecylphosphatidylethanolamines (DHPE, DH-N-methyl-PE (DHMePE) and DH-N,N-dimethyl-PE (DHMe
Viktor Ya Artukhov et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 68(1), 36-42 (2006-12-13)
Some important and essential features of absorption and fluorescence spectra of prodan in homogeneous and binary mixes are studied. According to results obtained from experimental and quantum-chemical researches we show that the absorption spectrum of prodan in nonpolar solvent within
Liping Zhou et al.
Analytical chemistry, 83(18), 6980-6987 (2011-07-28)
This paper describes for the first time, a high-throughput fluorescence noncell based assay to screen for the drug-phospholipid interaction, which correlates to phospholipidosis. Anionic amphiphilic phospholipids can form complexes in aqueous solution, and its critical micelle concentration (CMC) can be
A Chakrabarti
Biochemical and biophysical research communications, 226(2), 495-497 (1996-09-13)
A large blue-shift (delta lambda max = 87 nm) in the fluorescence emission maximum and 2-fold enhancement in the emission intensity of PRODAN in the presence of 1.5 microM dimeric spectrin from the same aqueous buffer was observed. Binding of
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