PHR1509

Epinephrine Bitartrate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): (−)-Epinephrine (+)-bitartrate salt, L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen bitartrate salt, L-Adrenaline (+)-bitartrate salt, L-Adrenaline D-hydrogentartrate, L-Epinephrine D-hydrogentartrate
• Empirical Formula (Hill Notation): C₉H₁₃NO₃ · C₄H₆O₆
• CAS Number: 51-42-3
• Molecular Weight: 333.29
• EC Number: 200-097-1
• MDL number: MFCD00035077
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823427
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 3; traceable to Ph. Eur. A0300000; traceable to USP 1237000
• API family: epinephrine
• CofA: current certificate can be downloaded
• packaging: ampule of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CNC[C@H](O)c1ccc(O)c(O)c1
• InChI: 1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
• InChI key: YLXIPWWIOISBDD-NDAAPVSOSA-N
• Gene Information: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Epinephrine belongs to the class of drugs termed as catecholamines, which exerts its action on both alpha and beta-adrenergic receptors using a G protein-linked second messenger system.

Application

Epinephrine bitartrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Adrenergic receptor agonist.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0282 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable