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USP

Captopril disulfide

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O6S2
CAS Number:
Molecular Weight:
432.55
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

captopril

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1

InChI key

ZWKRXBCJAUKDCI-KRCVMZOZSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Captopril disulfide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Captopril Tablets
  • Captopril
  • Captopril and Hydrochlorothiazide Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Participation of kinins or prostaglandins in SQ 14,551-induced immediate decrease of blood pressure in anesthetized dogs.
N O'Hara et al.
Japanese journal of pharmacology, 33(2), 485-488 (1983-04-01)
Electrochemical reduction of disulfides.
H Kadin
Methods in enzymology, 143, 257-264 (1987-01-01)
E Ivashkiv
Journal of pharmaceutical sciences, 73(10), 1427-1430 (1984-10-01)
Captopril disulfides and the drug covalently bound to proteins were reduced with tri-n-butylphosphine. After sample purification on an XAD-2 column, captopril was treated with 1-(7-dimethylamino)-4-methyl-2-oxo-2H -1-benzopyran-3-yl)-1H-pyrrole-2,5-dione to form a fluorescent derivative. After acidification, the fluorescent derivative was extracted into toluene
Managing hypertension in patients with renal disease.
J G Porush
Journal of the National Medical Association, 76 Suppl, 24-32 (1984-07-01)
Waleed M M Mahmoud et al.
Chemosphere, 88(10), 1170-1177 (2012-04-27)
In some countries effluents from hospitals and households are directly emitted into open ditches without any further treatment and with very little dilution. Under such circumstances photo- and biodegradation in the environment can occur. However, these processes do not necessarily

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