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SML3869

Sigma-Aldrich

Avibactam Sodium

≥98% (HPLC)

Synonym(s):

(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt, AVE1330A sodium salt, NXL-104 sodium salt, Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester sodium salt

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About This Item

Empirical Formula (Hill Notation):
C7H10N3NaO6S
CAS Number:
Molecular Weight:
287.23
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Avibactam is a reversible non-β-lactam β-lactamase inhibitor with IC50 values of 5 nM for CTX-M-15, 8nM for TEM-1, and 80 nM for P99 β-lactamase enzymes.

Caution

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Avibactam is a covalent, reversible, non-?-lactam ?-lactamase inhibitor
Proceedings of the National Academy of Sciences of the USA, 109(29), 11663-11668 (2012)
Carbapenemase Inhibitors: Updates on Developments in 2021
Journal of clinical medicine research, 14(7), 251-259 (2022)
Efficacies of ceftazidime-avibactam and ceftazidime against Pseudomonas aeruginosa in a murine lung infection model
Antimicrobial Agents and Chemotherapy, 58(3), 1365-1371 (2014)

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