SML0356

Etonogestrel

≥98% (HPLC)

• Synonym(s): (17α)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one, 3-Keto-desogestrel, 3-Oxo-desogestrel
• Empirical Formula (Hill Notation): C₂₂H₂₈O₂
• CAS Number: 54048-10-1
• Molecular Weight: 324.46
• EC Number: 258-936-2
• MDL number: MFCD00867863
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825358
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +80 to +95°, c = 1 (CHCl3)
• color: white to beige
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CC[C@]12CC(=C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C
• InChI: 1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
• InChI key: GCKFUYQCUCGESZ-BPIQYHPVSA-N
• Gene Information: human ... PGR(5241)

Description

Biochem/physiol Actions

Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol.

Etonogestrel is a third-generation progestin contraceptive. Etonogestrel is used as a contraceptive itself and is also the active metabolite of the drug desogestrel used in some combination contraceptives.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H351,H360
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Carc. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable