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246395

Sigma-Aldrich

4-Hydrazinobenzoic acid

97%

Synonym(s):

(4-Carboxyphenyl)hydrazine, (p-Carboxyphenyl)hydrazine, 4-Hydrazinylbenzoic acid, p-Hydrazinobenzoic acid

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About This Item

Linear Formula:
H2NNHC6H4CO2H
CAS Number:
Molecular Weight:
152.15
Beilstein:
387378
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

form

solid

mp

218 °C (dec.) (lit.)

functional group

carboxylic acid
hydrazine

SMILES string

NNc1ccc(cc1)C(O)=O

InChI

1S/C7H8N2O2/c8-9-6-3-1-5(2-4-6)7(10)11/h1-4,9H,8H2,(H,10,11)

InChI key

PCNFLKVWBDNNOW-UHFFFAOYSA-N

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Application

4-Hydrazinobenzoic acid was used in the synthesis of multi-substituted dihydropyrano[2,3-c]pyrazole derivatives.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Lucas F de Lima et al.
Talanta, 187, 113-119 (2018-06-02)
Aldehydes are relevant analytes in a wide range of samples, in particular, food and beverages but also body fluids. Hydrazines can undergo nucleophilic addition with aldehydes or ketones giving origin to hydrazones (a group of stable imines) that can be
Keyume Ablajan et al.
Molecular diversity, 17(4), 693-700 (2013-08-07)
A convenient and efficient synthesis of multi-substituted dihydropyrano[2,3-c]pyrazole derivatives is reported. The four-component reaction of 4-hydrazinobenzoic acid, β-keto esters, aromatic aldehydes, and malononitrile using 10 mol% CAN catalyst in water under ultrasound irradiation produced the target compounds in good-to-excellent yields.
Lin Chen et al.
Materials science & engineering. C, Materials for biological applications, 104, 109939-109939 (2019-09-11)
Folic acid-conjugated magnetic ordered mesoporous carbon nanospheres (FA-MOMCNs) are developed as a targeting delivery vehicle of doxorubicin (DOX) in this work. Investigations on DOX loading mechanism show that the loading capacity of FA-MOMCNs is up to 577.12 mg g-1 by means of
Shinji Oikawa et al.
Free radical research, 40(1), 31-39 (2005-11-22)
4-Hydrazinobenzoic acid, an ingredient of mushroom Agaricus bisporus, is carcinogenic to rodents. To clarify the mechanism of carcinogenesis, we investigated DNA damage by 4-hydrazinobenzoic acid using (32)P-labeled DNA fragments obtained from the human p53 and p16 tumor suppressor genes. 4-Hydrazinobenzoic
Anzhi Sheng et al.
Analytica chimica acta, 1104, 110-116 (2020-02-29)
Hydrazone chemistry has been firstly explored as capturing mode for interface supported toehold strand displacement cascade (TSDC). The method has been further established for analysis of 5-hydroxymethylfurfural (HMF) based on hydrazone chemistry-mediated TSDC. HMF containing aldehyde group can be covalently

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